This is theoretically true, but I think you'd have to get a lot of support from AMD and be responsible for implementing most of a traditional computer yourself.

This is theoretically true, but I think you'd have to get a lot of support from AMD and be responsible for implementing most of a traditional computer yourself. I have a feeling it's be roughly as feasible to do it all with fully custom hardware. Otoh if you just mean try to write software to minimize the need to hit memory, that's totally reasonable -- and what you have to do if you want the best performance.