If it's #1 it's god help humanity. A high lethality long latency disease won't be stopped in time to matter. If you can even stop it at all. However, you've

If it's #1 it's god help humanity. A high lethality long latency disease won't be stopped in time to matter. If you can even stop it at all. However, you've missed a #4--toxin from some factory in the area that has paid off the politicians.