2 ms·
He's talking about the Pfizer multi-national trial (which included a lot of enrollees in South Africa), and greatly distorting it. https://www.nejm.org/doi/ful
by mlyle 2y ago
He's talking about the Pfizer multi-national trial (which included a lot of enrollees in South Africa), and greatly distorting it.
https://www.nejm.org/doi/full/10.1056/NEJMoa2034577#t2 https://www.nejm.org/doi/full/10.1056/NEJMoa2034577#t2
Yes, the primary endpoint shown in here was comparing 7 days after dose 2 of the vaccine to 7 days after dose 2 of the placebo group. (table 2):
https://www.nejm.org/cms/10.1056/NEJMoa2034577/asset/619bcb14-245e-4b0e-80d8-b9d803517af6/assets/images/large/nejmoa2034577_t2.jpg https://www.nejm.org/cms/10.1056/NEJMoa2034577/asset/619bcb1...
However, figure 3 breaks down the efficacy vs. time, and it shows no effect like he describes:
https://www.nejm.org/cms/10.1056/NEJMoa2034577/asset/fe40d074-355a-416e-957c-0bb69ef30bfc/assets/images/large/nejmoa2034577_f3.jpg https://www.nejm.org/cms/10.1056/NEJMoa2034577/asset/fe40d07...
Instead, the vaccine and control groups were about the same until roughly day 10-12 after the first dose, and then dramatically diverged (though not as decisively as after dose 2).