5 ms·
Study is very dense. Did the study show that SSRI and other antidepressants change brain chemistry? That is, are we finally done with "SSRIs are essentially
by zzzeek 2y ago
Study is very dense. Did the study show that SSRI and other antidepressants change brain chemistry? That is, are we finally done with "SSRIs are essentially placebos" ?
- tsimionescu 2y agoI don't think there is any doubt that SSRIs change brain chemistry, at least temporarily. The risk of causing serotoninergic syndrome should be proof enough of that. The question is whether their mechanism of action truly helps in people with depression disorders or anxiety disorders or any of the other conditions they are prescribed for. We clearly know from clinical trials that it helps some, at least somewhat, and it doesn't help at all or even hurts in many others; and this remains true regardless of dose. We don't have any specific theory as to why this is.
- user_7832 2y agoIIRC it was found that the anti-inflammatory effects of SSRIs are partially responsible for their benefits