5 ms·
This is what worries me. I have devised a law of absolutes that is, "Nothing is all upside" or "Everything has unintended negative consequences". And the more s
by listless 2y ago
This is what worries me. I have devised a law of absolutes that is, "Nothing is all upside" or "Everything has unintended negative consequences". And the more something appears to be all upside, the more devastating the downside usually turns out to be.
- dsr_ 2y agoConstipation. Weight loss. Reduced blood sugar. Sometimes paresis (your digestive system stops working, mostly because you aren't eating enough.) All of those are at least sometimes undesirable.
- mdaverde 2y agoAgree with everything has trade offs but do not agree that they are equivalent in impact. Tradeoffs have tradeoffs
- silverquiet 2y agoWhile simple heuristics like that can get you quite far in life, it doesn't mean that they are laws of nature. I suppose time will ultimately tell, but these drugs are super widely used and apparently the class (GLP1 agonists) is not as novel as you might think; the blockbusters we see today are improved versions of drugs that have existed for awhile. If there was some horrible, monkey's paw catch, we'd likely have seen it by now. I suppose the biggest example of such a faustian weight-loss drug would be Fen-Phen, and it's issues were discovered within a few years of its rise to prominence.
- comova 2y agoHistory of medicine is full of incredible breakthroughs that are mostly upsides, like antibiotics, vaccines, new cancer immune therapies, etc. It happens!