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Will this drug ever stop giving? What does it do next? Stop dementia? Fix short-sightedness?
by choeger 2y ago
Will this drug ever stop giving? What does it do next? Stop dementia? Fix short-sightedness?
- deelowe 2y agoWell it's highly addictive for one...
- stevenae 2y agoI haven't seen this reported. Do you have a source?
- black6 2y agoAddictive or not, it's a long-term use pharmaceutical.
- karmajunkie 2y agoHave you got a citation for that? I've not seen anything that indicates the drug itself is addictive, though there's ample evidence that its effects wane quickly after discontinuation of therapy.
- lxe 2y agoSource? It's not habit-forming or addictive from what I'm reading.
- toomuchtodo 2y agoLooking forward to the gene therapy trial results. Going to be crazy ROI on bug fixing the human for this bug. Edit: https://www.fractyl.com/fractyl-health-demonstrates-significant-improvement-in-glucose-control-and-obesity-inpreclinical-studies-of-its-rejuva-glp-1-based-pancreatic-gene-therapy-glp1-pgtxcompared-to-chronic-semaglutide-at/ https://www.fractyl.com/fractyl-health-demonstrates-signific... https://www.remain1study.com/remain-1-study/ https://www.remain1study.com/remain-1-study/
- aantix 2y agoWhat exactly are they testing?
- Theodores 2y ago[flagged]
- nwienert 2y agoIt greatly reduces my autoimmune issues, another friend reported dramatic reduction in allergy issues...
- DANmode 2y agoAre you willing to share more about either? That's fascinating.
- nwienert 2y agoHave Ehlers Danlos and another thing, with quite a few effects I get ongoing, it's actually why I try experimenting with drugs in general. I wasn't much overweight but gave it a shot since it seemed like a fascinating drug, and the results were shocking to me. Perennial light sleeper, couldn't drink caffeine either due to extreme long half life and sleep issues. On it, fall asleep at night like a "normal" person for the first time. Able to drink coffee too. I chalked that up to the fact it does have a bit of a drowsiness effect, but... then I noticed I was just having a bit less back pain. Noticed my tingling in feet and muscle fasciculation was down. I've been on and off it now ever since, but I take lower doses/breaks since I don't need it for weight. But I was getting "attacks" of inflammation every ~6 months, since doing it for 1.5 years not a single attack (knock on wood). My thought there is - yes fasting is great for a lot of things and maybe helped, but I can't help but think it's other effect. I've tried a lot of things, even other peptides that supposedly work and had 0 effects across hundreds of supplements. This stuff had huge effects. The friend I can't speak to much, simply that they told me they started it and without my prompting told me a couple months later about the allergy thing.
- DANmode 2y agoThanks for sharing. I wonder how that works! Also, curious what type of allergy the friend has, and what type of relief.
- listless 2y agoThis is what worries me. I have devised a law of absolutes that is, "Nothing is all upside" or "Everything has unintended negative consequences". And the more something appears to be all upside, the more devastating the downside usually turns out to be.
- dsr_ 2y agoConstipation. Weight loss. Reduced blood sugar. Sometimes paresis (your digestive system stops working, mostly because you aren't eating enough.) All of those are at least sometimes undesirable.
- mdaverde 2y agoAgree with everything has trade offs but do not agree that they are equivalent in impact. Tradeoffs have tradeoffs
- silverquiet 2y agoWhile simple heuristics like that can get you quite far in life, it doesn't mean that they are laws of nature. I suppose time will ultimately tell, but these drugs are super widely used and apparently the class (GLP1 agonists) is not as novel as you might think; the blockbusters we see today are improved versions of drugs that have existed for awhile. If there was some horrible, monkey's paw catch, we'd likely have seen it by now. I suppose the biggest example of such a faustian weight-loss drug would be Fen-Phen, and it's issues were discovered within a few years of its rise to prominence.
- comova 2y agoHistory of medicine is full of incredible breakthroughs that are mostly upsides, like antibiotics, vaccines, new cancer immune therapies, etc. It happens!
- QuesnayJr 2y agoI'm still waiting to see if really does have all of the reported positive effects, but if holds up, then this suggests to me that the negative effects must have a common cause. There's some aspect of modern life that causes compulsive self-medicating behaviors, and we've stumbled on a treatment for it.
- raydev 2y agoI mean, it seems like all benefits can be summarized with "solves overconsumption problems".