5 ms·

Isn’t the article describing in depth how an experiment showed it possible or did I completely misread it? It even explained the mechanisms behind it?

• ch4s3 2y ago
  The article glosses over some details of a decade old study, that might have maybe shown that some types of conditioning using electrical shock might have epigenetic effects that persist in gametes and effect later behavior. The study attempts to show it indirectly and hand waves at the mechanisms. It doesn’t test for DNA methylation or anything similar.
  • oa335 2y ago
    They did test for and find hypomethylation. It’s mentioned in the article here: > How had this happened? The team discovered that the DNA in the grandfather mouse’s sperm had changed shape. … The gene for this olfactory receptor had been demethylated (chemically tagged), … As well as in the abstract of the linked study: > Bisulfite sequencing of sperm DNA from conditioned F0 males and F1 naive offspring revealed CpG hypomethylation in the Olfr151 gene. https://pubmed.ncbi.nlm.nih.gov/24292232/ https://pubmed.ncbi.nlm.nih.gov/24292232/
    • ch4s3 2y ago
      I must have missed that reading the study, and that certainly is a little more compelling. I'm still very skeptical about the way the guardian article presents the claims, and the lack of any mention of follow up work since the decade old study.