On audio work stations, swapping can lead to an interruption of the audio stream, which can manifest itself as garbled sound up until some very loud noise, not

On audio work stations, swapping can lead to an interruption of the audio stream, which can manifest itself as garbled sound up until some very loud noise, not unlike an explosion in a game, which is potentially damaging to the ear, depending on the listening level. So: limiters on all busses, and swap off. If your samples don't fit in memory, try another route.