If you _must_ use I2C, then look at SMBUS if its an option for the parts. I2C's biggest failing is that there is no protocol level timeout, so one stuck device

If you _must_ use I2C, then look at SMBUS if its an option for the parts. I2C's biggest failing is that there is no protocol level timeout, so one stuck device can block your entire bus unless you have a reset line for all the peripherals on it. https://www.analog.com/en/resources/design-notes/guide-to-comparing-ic-bus-to-the-smbus.html https://www.analog.com/en/resources/design-notes/guide-to-co...