You can do this through COM. I forgot which Python library I used but once you have an Excel application object you can do Data = xl.range('a1:a3') Sum = xl.

You can do this through COM. I forgot which Python library I used but once you have an Excel application object you can do Data = xl.range('a1:a3') Sum = xl.worksheetfunction.sum(data) Xl.range('b3').value = sum Any library enabling the COM link will do. (sorry, typing this on my phone so formatting and capitalization are screwy)