4 ms·

>I've begun taking a small amount of CBD in the form of an edible a few hours before going to bed (a quarter of a 5 mg gummy), and I have minimal sleep issues n

>I've begun taking a small amount of CBD in the form of an edible a few hours before going to bed (a quarter of a 5 mg gummy), and I have minimal sleep issues now. A 1.25mg dose of CBD is essentially homeopathic levels. Either you're confused on the dosage or experiencing a placebo effect.

wafflemaker 2y ago
Active doses vary wildly between people. And spectrum folks (which 30% of hners are) tend to need less of most drugs.
- newzisforsukas 2y ago
  > (which 30% of hners are) Where is this number from?
  - philwelch 2y ago
    Behind the pelvis
  - wil421 2y ago
    >need less of most drugs. This one too.
    - wafflemaker 2y ago
      Sorry, got that from one of Thomas D. Brown's books on ADHD. Thought it's a common knowledge, but I struggle to find anything on it on the internet. Source should be in the book tho. Drop me a message at ntgiem2q0rc@opayq.com and I'll reply when\if I find it. Can't ATM.
      - philwelch 2y ago
        Thomas D. Brown did a study on HN users and published his findings in a book?
  - monadINtop 2y ago
    it was revealed in a vision
itishappy 2y ago
Edit: This was a garbage-tier comment. Leaving it up with edits because I think the links are interesting. 1/4 "serving size" (if you will) isn't homeopathic, ~~and aligns pretty closely with the recommended dose of the only FDA approved CBD medication~~ (see edit below): > Increase in weekly increments of 5 mg/kg/day (2.5 mg/kg twice daily). Edit: I'm dumb and mixing mg and mg/kg. This would be 400mg/day for an average adult. Still not homeopathic. https://www.epidiolexhcp.com/dosing/dosing-and-administration https://www.epidiolexhcp.com/dosing/dosing-and-administratio... Though the ~~recommended dose~~ (again, see edit below) for various activities does vary wildly: > post-traumatic stress disorder (PTSD): 1.5 mg > difficulty sleeping: 300 mg Edit: Turns out that's just the dosage that was administered during one of the studies, not necessarily the recommended treatment dosage. > Despite these early findings and data from two case reports in which CBD improved sleep quality in a single pediatric patient with PTSD and four patients with Parkinson’s disease, we identified only one randomized, double-blind, placebo-controlled, study with sleep as the primary outcome measure. In this trial, 27 healthy volunteers received either oral CBD (300 mg dissolved in corn oil) or placebo. CBD did not alter any sleep measures (e.g., self-rated sleep quality or polysomnography examinations) relative to placebo. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880228/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880228/ We really need better studies of this stuff...
- dragonwriter 2y ago
  Are you mixing mg/kg with straight mg? You know the average patient weighs substantially more than 1kg, right?
  - itishappy 2y ago
    Yes. Damnit. Edited.
- ryaneager 2y ago
  No, it doesn’t. That says 5 mg per kilogram of bodyweight per day. He’s having 1.25 mg total per day.
- deleted 2y ago
  [deleted]
dragonwriter 2y ago
> A 1.25mg dose of CBD is essentially homeopathic levels. Homeopathic levels are a vanishingly small chance of their being a single molecule of the notional ingredient in a dose. 1.25mg is not even remotely “essentially homeopathic”.
- kjkjadksj 2y ago
  If you felt anything from so little I’d certainly call it placebo
swatcoder 2y ago
> experiencing a placebo effect And if that effect were satisfactory, as it sounds, why would that matter? Would you even know if it was a psychogenic remedy to what was probably a psychogenic malady in the first place, rather than a peculiar, individual sensitivity that just hasn't been identified in the sparse research on CBD? (You would not)

wafflemaker 2y ago

Active doses vary wildly between people. And spectrum folks (which 30% of hners are) tend to need less of most drugs.

newzisforsukas 2y ago
> (which 30% of hners are) Where is this number from?
- philwelch 2y ago
  Behind the pelvis
- wil421 2y ago
  >need less of most drugs. This one too.
  - wafflemaker 2y ago
    Sorry, got that from one of Thomas D. Brown's books on ADHD. Thought it's a common knowledge, but I struggle to find anything on it on the internet. Source should be in the book tho. Drop me a message at ntgiem2q0rc@opayq.com and I'll reply when\if I find it. Can't ATM.
    - philwelch 2y ago
      Thomas D. Brown did a study on HN users and published his findings in a book?
- monadINtop 2y ago
  it was revealed in a vision

itishappy 2y ago

Edit: This was a garbage-tier comment. Leaving it up with edits because I think the links are interesting. 1/4 "serving size" (if you will) isn't homeopathic, ~~and aligns pretty closely with the recommended dose of the only FDA approved CBD medication~~ (see edit below): > Increase in weekly increments of 5 mg/kg/day (2.5 mg/kg twice daily). Edit: I'm dumb and mixing mg and mg/kg. This would be 400mg/day for an average adult. Still not homeopathic. https://www.epidiolexhcp.com/dosing/dosing-and-administration https://www.epidiolexhcp.com/dosing/dosing-and-administratio... Though the ~~recommended dose~~ (again, see edit below) for various activities does vary wildly: > post-traumatic stress disorder (PTSD): 1.5 mg > difficulty sleeping: 300 mg Edit: Turns out that's just the dosage that was administered during one of the studies, not necessarily the recommended treatment dosage. > Despite these early findings and data from two case reports in which CBD improved sleep quality in a single pediatric patient with PTSD and four patients with Parkinson’s disease, we identified only one randomized, double-blind, placebo-controlled, study with sleep as the primary outcome measure. In this trial, 27 healthy volunteers received either oral CBD (300 mg dissolved in corn oil) or placebo. CBD did not alter any sleep measures (e.g., self-rated sleep quality or polysomnography examinations) relative to placebo. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880228/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880228/ We really need better studies of this stuff...

dragonwriter 2y ago
Are you mixing mg/kg with straight mg? You know the average patient weighs substantially more than 1kg, right?
- itishappy 2y ago
  Yes. Damnit. Edited.
ryaneager 2y ago
No, it doesn’t. That says 5 mg per kilogram of bodyweight per day. He’s having 1.25 mg total per day.
deleted 2y ago
[deleted]

dragonwriter 2y ago

> A 1.25mg dose of CBD is essentially homeopathic levels. Homeopathic levels are a vanishingly small chance of their being a single molecule of the notional ingredient in a dose. 1.25mg is not even remotely “essentially homeopathic”.

kjkjadksj 2y ago
If you felt anything from so little I’d certainly call it placebo

swatcoder 2y ago

> experiencing a placebo effect And if that effect were satisfactory, as it sounds, why would that matter? Would you even know if it was a psychogenic remedy to what was probably a psychogenic malady in the first place, rather than a peculiar, individual sensitivity that just hasn't been identified in the sparse research on CBD? (You would not)