> Doesn't this just say that being exposed to more, and perhaps different, microbials will trigger your immune system? There are lots of words, but my casual ey

> Doesn't this just say that being exposed to more, and perhaps different, microbials will trigger your immune system? There are lots of words, but my casual eyes don't read anything that would be non-obvious. There are many studies which evaluate things that seem obvious. These are necessary to support less obvious conclusions in other studies. If your paper is going to make the claim that IL10 upregulation in children as a consequence of environmental stimuli is linked to some disease process, one of the critiques will be if you can even establish that IL10 upregulation reliably occurs. If your paper can cite a well-performed study evaluating that prior, it strengthens the conclusions of your own study.