5 ms·

Magnesium in Drug Abuse and Addiction (2011)

28 points by Spod_Gaju 2y ago

fluxist 2y ago
Such a commonly available intervention, I'm a bit skeptical that this works. In my own first-person experience, magnesium supplementation has had no discernable effect on Cocaine Use Disorder. N-acetylcysteine (NAC), on the other hand, has had a minor but noticeable ability to mitigate cravings.[1] [1] https://pubmed.ncbi.nlm.nih.gov/28213190/ https://pubmed.ncbi.nlm.nih.gov/28213190/
- Spod_Gaju 2y ago
  I am sure magnesium is in no way universal cure. But interestingly cysteine is used to reduce ATP so you might have the same condition I have, which is instead of low ATP, high ATP. High ATP could end up, creating a lot of oxidative stress in the mitochondria and end up inhibiting ATP as well. And the cystine can reduce oxidative stress inside the mitochondria to repair it. https://www.uniprot.org/uniprotkb/P48506/entry https://www.uniprot.org/uniprotkb/P48506/entry
viggity 2y ago
As someone who has been a pain patient for a decade and a half, and as someone who has been supplementing with magnesium off and on for even longer... If you're a pain patient you should definitely investigate this, and probably just supplement and see how it goes. I certainly feel better about my relationship with opioids when I'm consistent about my magnesium.
- Spod_Gaju 2y ago
  Magnesium will increase ATP. And ATP is the energy that is needed to sensitize G protein coupled receptors. One of those G protein coupled receptors is the opioid receptor. So what magnesium is doing is making your opioid receptors more sensitive to your natural opioids.
  - Projectiboga 2y ago
    I think severe withdrawals are associated with Magnesium deficiency. This research has been going on for decades as there isn't a dose response curve for how severe a narcotic withdrawal will be based on dosing alone.
hi-v-rocknroll 2y ago
Some people use magnesium citrate for GI motility and reduce calcium oxalate kidney stone formation. In higher doses, it's used as a pre-surgical laxative.

28 points by Spod_Gaju 2y ago

Such a commonly available intervention, I'm a bit skeptical that this works. In my own first-person experience, magnesium supplementation has had no discernable effect on Cocaine Use Disorder. N-acetylcysteine (NAC), on the other hand, has had a minor but noticeable ability to mitigate cravings.[1] [1] https://pubmed.ncbi.nlm.nih.gov/28213190/ https://pubmed.ncbi.nlm.nih.gov/28213190/

Spod_Gaju 2y ago
I am sure magnesium is in no way universal cure. But interestingly cysteine is used to reduce ATP so you might have the same condition I have, which is instead of low ATP, high ATP. High ATP could end up, creating a lot of oxidative stress in the mitochondria and end up inhibiting ATP as well. And the cystine can reduce oxidative stress inside the mitochondria to repair it. https://www.uniprot.org/uniprotkb/P48506/entry https://www.uniprot.org/uniprotkb/P48506/entry

viggity 2y ago

As someone who has been a pain patient for a decade and a half, and as someone who has been supplementing with magnesium off and on for even longer... If you're a pain patient you should definitely investigate this, and probably just supplement and see how it goes. I certainly feel better about my relationship with opioids when I'm consistent about my magnesium.

Spod_Gaju 2y ago
Magnesium will increase ATP. And ATP is the energy that is needed to sensitize G protein coupled receptors. One of those G protein coupled receptors is the opioid receptor. So what magnesium is doing is making your opioid receptors more sensitive to your natural opioids.
- Projectiboga 2y ago
  I think severe withdrawals are associated with Magnesium deficiency. This research has been going on for decades as there isn't a dose response curve for how severe a narcotic withdrawal will be based on dosing alone.

hi-v-rocknroll 2y ago

Some people use magnesium citrate for GI motility and reduce calcium oxalate kidney stone formation. In higher doses, it's used as a pre-surgical laxative.