4 ms·

Do you know if there’s been any advancement on the cause? Last I checked, my cocktail party understanding was it trained immune cells to attack parts of the ner

Do you know if there’s been any advancement on the cause? Last I checked, my cocktail party understanding was it trained immune cells to attack parts of the nervous system. So long Covid was (sometimes) a bit like having transitory multiple sclerosis. I probably misunderstood the explanation. I just hope there ongoing research. I miss physics Girl on YouTube.

PaulKeeble 2y ago
No treatment or trial has yet been effective enough to suggest it points to the root of a singular disease pathology. There is evidence of viral persistence (even those without Long Covid), auto immune antibodies and dysfunction immune T and B cells and a host of metabolic and cellular adjustments as well as clotting and a host of other issues, its completely systemic and that makes it really hard to pick apart. I don't know if the research will get down to one thing or a multitude of treatments or how quickly its going to be, things are going quite slowly its a very complex disease. Nothing is in development yet directly targeting it due to a lack of accepted biomarker and true understanding. Its not that we don't know a lot we just don't know which bits matter and whether existing treatments work on them. Its pretty concerning, that there is no treatments let alone a cure, because every infection can cause Long Covid. Its about 13% chance every time you catch Covid. There is no lasting immunity to Covid or Long Covid that we know of nor genetic commonality. Current CDC projections suggests everyone will have this disease in their life and recovery is very rare. We are looking at a worldwide disabling event and not a lot of research money to get to the bottom of it from governments nor any social support for the 100s of millions already disabled by it.
- azinman2 2y ago
  Are there 100s of millions already disabled by it? You hear of it, but I feel like if the disabling was in hundreds of millions it would get more attention than it does.
  - spondylosaurus 2y ago
    Commenting as a placeholder to come back to check for replies later because I'm also curious. And for a bit of comparative context (which I always find helpful), the population of California is about 40 million. So a hundred million is about two and a half Californias.
  - pjc50 2y ago
    On the other hand, ONS UK estimates about 3% https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/prevalenceofongoingsymptomsfollowingcoronaviruscovid19infectionintheuk/30march2023 https://www.ons.gov.uk/peoplepopulationandcommunity/healthan... , and 3% of eight billion is 240m people. We already know that disability in general tends to be rendered invisible unless it's a really widespread condition, and long covid symptoms are themselves invisible to others.
- avgDev 2y ago
  I think there has been some research showing long covid often causes dysautonomia, which is dysfunction of autonomic nervous system. This results in many weird symptoms affecting many different bodily functions. This is why many dysautonomia clinics are seeing long covid patients. If long covid patient shows damage to small or large nerve fibers tested by EMG, skin punch and QSART, there is some treatments in the pipeline. WinSanTor is working on a cream which uses pirenzepine. In early studies it reversed nerve damage. It is being tested on diabetic neuropathy. Also, applying dysautonomia life style changes could potentially help people cope right now. I have spoken directly to a chemist who took oral pirenzepine and cured his dysautonomia.

PaulKeeble 2y ago

No treatment or trial has yet been effective enough to suggest it points to the root of a singular disease pathology. There is evidence of viral persistence (even those without Long Covid), auto immune antibodies and dysfunction immune T and B cells and a host of metabolic and cellular adjustments as well as clotting and a host of other issues, its completely systemic and that makes it really hard to pick apart. I don't know if the research will get down to one thing or a multitude of treatments or how quickly its going to be, things are going quite slowly its a very complex disease. Nothing is in development yet directly targeting it due to a lack of accepted biomarker and true understanding. Its not that we don't know a lot we just don't know which bits matter and whether existing treatments work on them. Its pretty concerning, that there is no treatments let alone a cure, because every infection can cause Long Covid. Its about 13% chance every time you catch Covid. There is no lasting immunity to Covid or Long Covid that we know of nor genetic commonality. Current CDC projections suggests everyone will have this disease in their life and recovery is very rare. We are looking at a worldwide disabling event and not a lot of research money to get to the bottom of it from governments nor any social support for the 100s of millions already disabled by it.

azinman2 2y ago
Are there 100s of millions already disabled by it? You hear of it, but I feel like if the disabling was in hundreds of millions it would get more attention than it does.
- spondylosaurus 2y ago
  Commenting as a placeholder to come back to check for replies later because I'm also curious. And for a bit of comparative context (which I always find helpful), the population of California is about 40 million. So a hundred million is about two and a half Californias.
- pjc50 2y ago
  On the other hand, ONS UK estimates about 3% https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/prevalenceofongoingsymptomsfollowingcoronaviruscovid19infectionintheuk/30march2023 https://www.ons.gov.uk/peoplepopulationandcommunity/healthan... , and 3% of eight billion is 240m people. We already know that disability in general tends to be rendered invisible unless it's a really widespread condition, and long covid symptoms are themselves invisible to others.
avgDev 2y ago
I think there has been some research showing long covid often causes dysautonomia, which is dysfunction of autonomic nervous system. This results in many weird symptoms affecting many different bodily functions. This is why many dysautonomia clinics are seeing long covid patients. If long covid patient shows damage to small or large nerve fibers tested by EMG, skin punch and QSART, there is some treatments in the pipeline. WinSanTor is working on a cream which uses pirenzepine. In early studies it reversed nerve damage. It is being tested on diabetic neuropathy. Also, applying dysautonomia life style changes could potentially help people cope right now. I have spoken directly to a chemist who took oral pirenzepine and cured his dysautonomia.