3 ms·
There is NO tolerance development, on the contrary, increasing vascular health by long term PDE5 treatment and increasing psychological confidence over time mak
by Traubenfuchs 2y ago
There is NO tolerance development, on the contrary, increasing vascular health by long term PDE5 treatment and increasing psychological confidence over time make the treatment more effective with time.
https://www.sciencedirect.com/science/article/pii/S2050116119300650 https://www.sciencedirect.com/science/article/pii/S205011611...
- The_Colonel 2y agoYou're taking about slightly different things - you about ED, the other person about "boner all day". They are not the same thing. Slightly off topic, but this is why I don't really trust these "no tolerance" claims. That claim is usually very specific, while people's understanding of "tolerance" is often quite a bit wider. I take 3 medications which each make "no tolerance" claims based on scientific studies. But my subjective experience is that all of them do build tolerance in some way - the subjective effect does wear off with time and taking a break does reduce the tolerance. One possible cause is mistaking the intended effect (ED) with side-effects (boner all day).
- zolbrek 2y agoThe first time I took sildenafil I had a bad headache and nausea, the next couple of times I didn't suffer from nausea and the headache wasn't as severe. I don't suffer from any side effects now other than my nose getting a bit stuffy every now and then, so in that sense I developed a tolerance to the medication's side effects. The boner effects still work just as reliably as day one, no tolerance development for me there.
- rickydroll 2y agoyou are lucky, in addition to the migraines and stuffy nose, sildenafil altered my vision making everything looked blue tinted. I tried a couple other drugs in that class but the migraines never went away.