For current systems, sure, a developer might want to make it difficult to run their game in an emulator to deter piracy. There were a handful of Wii games which

For current systems, sure, a developer might want to make it difficult to run their game in an emulator to deter piracy. There were a handful of Wii games which did that since Dolphin matured while new Wii games were still being released. Nobody is making new commercial PS2 games anymore though, so any anti-emulator trick that wasn't deployed back in the day is never going to matter in practice.