Not coming from Bioinformatics. But we had a similar question regarding time series modelling a while ago. We used kind of modified arima models and it was diff

Not coming from Bioinformatics. But we had a similar question regarding time series modelling a while ago. We used kind of modified arima models and it was difficult to do it in python. For the rest we used python, especially for ML stuff and tried to keep the R part rather small Tldr: R for classical stats, python for machine learning