3 ms·

The audacity you have to claim causality here is wild. I’m a geneticist and boy let me tell you that it is not easy to unravel causality. Even in the systems I’

The audacity you have to claim causality here is wild. I’m a geneticist and boy let me tell you that it is not easy to unravel causality. Even in the systems I’ve studied for years, I would never make claims like this.

OutOfHere 2y ago
If you are a geneticist, you would know genetic correlates. The only causality of AD that I assert is with lifestyle factors and genetic factors, e.g. APOE4, that govern neuroinflammation, as is strongly established.
- naijaboiler 2y ago
  please just shush! you are still misleading people. Where the proof that lifestyle factors are causal and not just associative.
  - OutOfHere 2y ago
    With regard to lifestyle factors, here is some evidence to get you started: Healthy lifestyle and the risk of Alzheimer dementia (PMC7455318) > Compared to participants with 0 to 1 healthy lifestyle factor, the risk of Alzheimer dementia was 37% lower (pooled HR 0.63, 95% CI 0.47–0.84) in those with 2 to 3 healthy lifestyle factors and 60% lower (pooled HR 0.40, 95% CI 0.28–0.56) in those with 4 to 5 healthy lifestyle factors.
    - naijaboiler 2y ago
      thats still not causality. silly.
- catlikesshrimp 2y ago
  I hear this everyday, unfortunately: "If you really know something about [X], you must agree with my [opinion,unbased statements]" The nerve
  - OutOfHere 2y ago
    It's not opinion when there is evidence: APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease (PMID: 38710950) > The study concludes that APOE4 homozygotes represent a genetic form of AD Healthy lifestyle and the risk of Alzheimer dementia (PMC7455318) > Compared to participants with 0 to 1 healthy lifestyle factor, the risk of Alzheimer dementia was 37% lower (pooled HR 0.63, 95% CI 0.47–0.84) in those with 2 to 3 healthy lifestyle factors and 60% lower (pooled HR 0.40, 95% CI 0.28–0.56) in those with 4 to 5 healthy lifestyle factors.
  - deleted 2y ago
    [deleted]

OutOfHere 2y ago

If you are a geneticist, you would know genetic correlates. The only causality of AD that I assert is with lifestyle factors and genetic factors, e.g. APOE4, that govern neuroinflammation, as is strongly established.

naijaboiler 2y ago
please just shush! you are still misleading people. Where the proof that lifestyle factors are causal and not just associative.
- OutOfHere 2y ago
  With regard to lifestyle factors, here is some evidence to get you started: Healthy lifestyle and the risk of Alzheimer dementia (PMC7455318) > Compared to participants with 0 to 1 healthy lifestyle factor, the risk of Alzheimer dementia was 37% lower (pooled HR 0.63, 95% CI 0.47–0.84) in those with 2 to 3 healthy lifestyle factors and 60% lower (pooled HR 0.40, 95% CI 0.28–0.56) in those with 4 to 5 healthy lifestyle factors.
  - naijaboiler 2y ago
    thats still not causality. silly.
catlikesshrimp 2y ago
I hear this everyday, unfortunately: "If you really know something about [X], you must agree with my [opinion,unbased statements]" The nerve
- OutOfHere 2y ago
  It's not opinion when there is evidence: APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease (PMID: 38710950) > The study concludes that APOE4 homozygotes represent a genetic form of AD Healthy lifestyle and the risk of Alzheimer dementia (PMC7455318) > Compared to participants with 0 to 1 healthy lifestyle factor, the risk of Alzheimer dementia was 37% lower (pooled HR 0.63, 95% CI 0.47–0.84) in those with 2 to 3 healthy lifestyle factors and 60% lower (pooled HR 0.40, 95% CI 0.28–0.56) in those with 4 to 5 healthy lifestyle factors.
- deleted 2y ago
  [deleted]