In effect I asserted that neuroinflammation is at the root of AD, and that factors that lower it will in turn lower the risk of AD. This I stand by completely,

In effect I asserted that neuroinflammation is at the root of AD, and that factors that lower it will in turn lower the risk of AD. This I stand by completely, and so the lifestyle factors that lower neuroinflammation are relevant. As for PMID 38753870, it is just one of many relevant studies showing brain health benefits from urolithin A. In particular, urolithin A works by inducing mitophagy (among its many other effects), with mitophagy improving mitochondrial health and therefore metabolic health. Unhealthy lifestyle choices compromise the excitatory/inhibitory balance in the brain, and it goes downhill from there.