> i.e., gene editing (by whatever means) is not really a win any more than changing bits in memory is. The win comes from having an in-vitro model that replicat

> i.e., gene editing (by whatever means) is not really a win any more than changing bits in memory is. The win comes from having an in-vitro model that replicates the in-vivo disease I take your point, but this would have been a challenging, expensive endeavor before CRISPR-Cas9. Likely, the perturbation would not have been done in the same paper as the announcement of the locus due to the challenge of deletion work before CRISPR-Cas systems became readily available