The best scalability I knew about was JanusGraph running on ScyllaDB. You can also run JanusGraph on Cassandra, which is horizontally scalable. ScyllaDB will be

The best scalability I knew about was JanusGraph running on ScyllaDB. You can also run JanusGraph on Cassandra, which is horizontally scalable. ScyllaDB will be more performant and vertically scalable. • Docs: https://docs.janusgraph.org/storage-backend/scylladb/ https://docs.janusgraph.org/storage-backend/scylladb/ • Detailed use case: https://www.scylladb.com/2019/05/14/powering-a-graph-data-system-with-scylla-janusgraph/ https://www.scylladb.com/2019/05/14/powering-a-graph-data-sy... • Video: https://www.youtube.com/watch?v=7WZyVUTwYJ4 https://www.youtube.com/watch?v=7WZyVUTwYJ4 Note this was a few years ago. I haven't seen a TigerGraph vs. JanusGraph head-to-head. The TigerGraph people are pretty sharp. If anyone has deeper knowledge would love to see comparative benchmarks. Both JanusGraph and TigerGraph are rated about the same in terms of popularity on DB-engines.com (between 100-150 rankings). Neo4j is still far more popular/well-known, at rank #21 this past month. But there are other options you can explore.