3 ms·
What is better about the newer ones that there is so much hype? Or did it take 30 years to realise the other positive effects of these?
by Rastonbury 2y ago
What is better about the newer ones that there is so much hype? Or did it take 30 years to realise the other positive effects of these?
- deleted 2y ago[deleted]
- ewoodrich 2y agoA few things: 1. Weekly vs daily administration, liraglutide and exenatide had to be injected daily which made the drug less attractive for patients and doctors vs metformin which is well known and a cheap pill. 2. Greater magnitude of effect. Liraglutide had less impact at prescribed dosage for both lowering A1C and weight loss so in combo with (1) made it less attractive than semaglutide. 3. Magnitude of weight loss from (2) now so significant it easily beats all previously approved weight loss drugs with few side effects. So entire GLP-1 agonist class of drugs reexamined as direct weight loss treatments vs just a modest but very welcome side effect of diabetes treatment. And once weekly administration meant it would have much better patient compliance than a daily injection.
- Rastonbury 2y agoGreat summary thanks