4 ms·
You know that GLP-1s aren't new, right? There are diabetics who have been on them continuously for decades; it's only the realization that they can treat obesit
by Analemma_ 2y ago
You know that GLP-1s aren't new, right? There are diabetics who have been on them continuously for decades; it's only the realization that they can treat obesity which is new. If there were common and severe side-effects from continuous long-term use, they'd already have shown up in diabetic patients.
- Rastonbury 2y agoWhat is better about the newer ones that there is so much hype? Or did it take 30 years to realise the other positive effects of these?
- deleted 2y ago[deleted]
- ewoodrich 2y agoA few things: 1. Weekly vs daily administration, liraglutide and exenatide had to be injected daily which made the drug less attractive for patients and doctors vs metformin which is well known and a cheap pill. 2. Greater magnitude of effect. Liraglutide had less impact at prescribed dosage for both lowering A1C and weight loss so in combo with (1) made it less attractive than semaglutide. 3. Magnitude of weight loss from (2) now so significant it easily beats all previously approved weight loss drugs with few side effects. So entire GLP-1 agonist class of drugs reexamined as direct weight loss treatments vs just a modest but very welcome side effect of diabetes treatment. And once weekly administration meant it would have much better patient compliance than a daily injection.
- Rastonbury 2y agoGreat summary thanks
- deleted 2y ago[deleted]