4 ms·
Interesting findings but is a sample size of 30 particularly useful? I dont know much about statistics or how studies like this are usually done. Does someone m
by MeImCounting 2y ago
Interesting findings but is a sample size of 30 particularly useful? I dont know much about statistics or how studies like this are usually done. Does someone more educated want to chime in on the results particularly in context to the small sample size?
- smarm52 2y agoThe article doesn't seem to cite the paper (grumble), but this looks like it: Blundell, J., Finlayson, G., Axelsen, M., Flint, A., Gibbons, C., Kvist, T., & Hjerpsted, J. B. (2017). Effects of once‐weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity. Diabetes, Obesity and Metabolism, 19(9), 1242-1251. Then: > This randomised, double-blind, placebo-controlled, two-period crossover trial ... The "randomised, double-blind, placebo-controlled" is a "gold standard" sort of study. Then: > ... led to a lower ad libitum energy intake during lunch (−1255 kJ; P < .0001) and during the subsequent evening meal ( P = .0401) and snacks ( P = .0034), resulting in a 24% reduction in total energy intake across all ad libitum meals throughout the day (−3036 kJ; P < .0001). Some pretty big effect sizes. But they do cite some concerns about the "crossover" portion of the design: > With regard to changes in weight and body composition, however, this trial could be conversely limited by the crossover design. And ~30 is a pretty good sample size, as a rule of thumb. (Disclaimer: I am not a researcher in this area.)