I'd hate to tell you to switch DEs, but I ran into this same issue with my Framework 13. After using GNOME for almost 20 years it got me to try KDE which suppor

I'd hate to tell you to switch DEs, but I ran into this same issue with my Framework 13. After using GNOME for almost 20 years it got me to try KDE which supports that feature natively. Now none of my applications are blurry or require tweaking. I hadn't really used KDE much before that, but KDE 6 is a solid release.