4 ms·

What are the symptoms?

chasil 2y ago
Symptoms of toxoplasmosis are only present in the immuno-compromised. The behavioral changes are a different story. https://en.m.wikipedia.org/wiki/Toxoplasmosis https://en.m.wikipedia.org/wiki/Toxoplasmosis
- Tijdreiziger 2y ago
  I’ve always found the term ‘immunocompromised’ to be somewhat vague. I use immunosuppressive medication to manage a chronic condition, so I assume my immune function is worse than someone not using such, but better than e.g. someone undergoing chemotherapy. Does this make me immunocompromised or not? Or, where does it place me on the scale? What precautions should I take?
  - deleted 2y ago
    [deleted]
  - jimmygrapes 2y ago
    You're also immunocompromised if you slept poorly or are dehydrated or malnourished (as many are, even if they don't know it). I agree that it's a poor blanket term.
  - chasil 2y ago
    The question is how your medication interacts with "somatic hypermutation" which enables your dendritic cells to launch the cascade via t-cells which triggers antibody production by your b-cells. It would be useful to understand how your medication interacts with this process. https://m.youtube.com/watch?v=lXfEK8G8CUI https://m.youtube.com/watch?v=lXfEK8G8CUI Somatic hypermutation has a small discussion in the Kerzegast book. I understand that somatic hypermutation, by the removal of uracil, plays two roles, first in initial recognition of a pathogen, then second in tuning the response for variants. As I understand it, this only happens in germinal centers, the lymph nodes. https://www.scribd.com/document/664375598/IMMUNE-by-Philipp-Dettmer-PR https://www.scribd.com/document/664375598/IMMUNE-by-Philipp-... This is a question for an infectious disease specialist.
    - chasil 2y ago
      https://en.m.wikipedia.org/wiki/Somatic_hypermutation https://en.m.wikipedia.org/wiki/Somatic_hypermutation
retrac 2y ago
If it is not controlled by the immune system, it causes general neurological disorder, potentially severe (Parkinson-like, dementia, brain damage), and can start to invade other organs. This is uncommon except in people with serious immune dysfunction. When an infection is latent, it's normally described as asymptomatic. But there is some reason to think, it might subtly affect humans neurologically in a similar way to how it seems to affect other mammals, like the wolves in this article. But this is controversial.
- quantified 2y ago
  Also, like many other things, possibly linked to depression.

Symptoms of toxoplasmosis are only present in the immuno-compromised. The behavioral changes are a different story. https://en.m.wikipedia.org/wiki/Toxoplasmosis https://en.m.wikipedia.org/wiki/Toxoplasmosis

Tijdreiziger 2y ago
I’ve always found the term ‘immunocompromised’ to be somewhat vague. I use immunosuppressive medication to manage a chronic condition, so I assume my immune function is worse than someone not using such, but better than e.g. someone undergoing chemotherapy. Does this make me immunocompromised or not? Or, where does it place me on the scale? What precautions should I take?
- deleted 2y ago
  [deleted]
- jimmygrapes 2y ago
  You're also immunocompromised if you slept poorly or are dehydrated or malnourished (as many are, even if they don't know it). I agree that it's a poor blanket term.
- chasil 2y ago
  The question is how your medication interacts with "somatic hypermutation" which enables your dendritic cells to launch the cascade via t-cells which triggers antibody production by your b-cells. It would be useful to understand how your medication interacts with this process. https://m.youtube.com/watch?v=lXfEK8G8CUI https://m.youtube.com/watch?v=lXfEK8G8CUI Somatic hypermutation has a small discussion in the Kerzegast book. I understand that somatic hypermutation, by the removal of uracil, plays two roles, first in initial recognition of a pathogen, then second in tuning the response for variants. As I understand it, this only happens in germinal centers, the lymph nodes. https://www.scribd.com/document/664375598/IMMUNE-by-Philipp-Dettmer-PR https://www.scribd.com/document/664375598/IMMUNE-by-Philipp-... This is a question for an infectious disease specialist.
  - chasil 2y ago
    https://en.m.wikipedia.org/wiki/Somatic_hypermutation https://en.m.wikipedia.org/wiki/Somatic_hypermutation

retrac 2y ago

If it is not controlled by the immune system, it causes general neurological disorder, potentially severe (Parkinson-like, dementia, brain damage), and can start to invade other organs. This is uncommon except in people with serious immune dysfunction. When an infection is latent, it's normally described as asymptomatic. But there is some reason to think, it might subtly affect humans neurologically in a similar way to how it seems to affect other mammals, like the wolves in this article. But this is controversial.

quantified 2y ago
Also, like many other things, possibly linked to depression.