So what? Different cell types have different states of differentiation. For example, an M0 macrophage can become an M1 or M2 macrophage depending on its environ

So what? Different cell types have different states of differentiation. For example, an M0 macrophage can become an M1 or M2 macrophage depending on its environment. How is instability novel in a domain centered around the concept of adapt or die?