4 ms·

I think ketamine is niche, and it will remain so. It's one of many tools. MDMA also assists in restoring brain plasticity[0]. For me, by far the most interesti

I think ketamine is niche, and it will remain so. It's one of many tools. MDMA also assists in restoring brain plasticity[0]. For me, by far the most interesting development in mental health is Chris Palmer's work, which asserts that most mental illness is primarily a metabolic issue. If you think that can't be possible, read his 2022 book[1]. Here's a podcast[2]. [0] https://www.nature.com/articles/d41586-022-02871-w https://www.nature.com/articles/d41586-022-02871-w [1] https://www.amazon.com/Brain-Energy-Revolutionary-Understanding-Health/dp/1637741588/ https://www.amazon.com/Brain-Energy-Revolutionary-Understand... [2] https://www.youtube.com/watch?v=oC-sQogfh3Q https://www.youtube.com/watch?v=oC-sQogfh3Q

TexanFeller 2y ago
I think you are wrong. I've been getting ketamine treatment and it's nothing short of miraculous. The clinics are all booked solid because of so many referrals from patients. I'm pondering how I can invest in these clinics.
- xenospn 2y ago
  Lots of new startups around.
- Jerrrrry 2y ago
  Lots of new chemicals to patent, too. Arylcyclohexylamines are awesome.
tcj_phx 2y ago
Dr. Palmer's book was inspired by his discovery of the 80+ years of research establishing that "mental health" diagnoses are caused by metabolic problems. > Metabolic abnormalities have been identified in the brains and bodies of people with mental illness since the 1940's. > We have a plethora of scientific research to support this. > https://twitter.com/ChrisPalmerMD/status/1675801721820332032 https://twitter.com/ChrisPalmerMD/status/1675801721820332032 I don't think the ketogenic diet is the best intervention, but it's a start. My friend figured out that she's a poor methylator who is harmed by the food fortification folic acid. Adding a methylated form of Vitamin B-9 to her routine flipped a switch for her, from "depressed" to "not-depressed", but the mental health professionals forced on her didn't care. Dr. Palmer tweeted about his professional colleagues hurting people like my friend with anti-psychotics. While tranquilizers make the patient's symptoms seem better, they also harm the patient's metabolism. Whoops. This submission about ultra-processed foods was on the front page earlier today: https://news.ycombinator.com/item?id=40486504 https://news.ycombinator.com/item?id=40486504
AtlasBarfed 2y ago
I get depression and activity/exercise aren't easy to marry, but exercise and getting fit seems like a much better thing to try before mdma or LSD burns. Exercise is supposedly superior to all pharma antidepressants. And in the vein of the metabolic stuff, exercise can change your gut bacteria and metabolism on a fundamental level that isn't as fringe, it's pretty well documented. But it takes like a month to get the train rolling, no pill popping. Exercise helps with sleep regulation. Exercise helps with pooping regularly. Exercise helps moderate appetite, excessive or inability to eat. A very underrated aspect is it increases your pain threshold. Depressives have tested as less pain tolerant and if the correlation is a factor, exercise helps. There's probably 20 other aspects.
- lll-o-lll 2y ago
  Seconding exercise is the single best and easiest way to help. Intense exercise, but can be short. Consult the GP before flogging yourself to avoid unexpected death.
- krzat 2y ago
  Exercise, therapy and some kindness/compassion mindfulness. Very powerful stuff.
eellpp 2y ago
Will read through this. But have a quick question: Would it not be reasonable to guess that people having mental issues will have metabolic issues developed as later side effects. The reason is that mental issues puts a person in confused/lost state along with all the anxiety/feelings that it induces. This will causes them to neglect taking care of their body needs. Then that should trigger metabolic changes.
bentt 2y ago
Yes. I scanned the OP link for any mention of nutrition, the gut or microbiome and there was nothing. Such a disappointing oversight for a supposed expert on depression.

TexanFeller 2y ago

I think you are wrong. I've been getting ketamine treatment and it's nothing short of miraculous. The clinics are all booked solid because of so many referrals from patients. I'm pondering how I can invest in these clinics.

xenospn 2y ago
Lots of new startups around.
Jerrrrry 2y ago
Lots of new chemicals to patent, too. Arylcyclohexylamines are awesome.

tcj_phx 2y ago

Dr. Palmer's book was inspired by his discovery of the 80+ years of research establishing that "mental health" diagnoses are caused by metabolic problems. > Metabolic abnormalities have been identified in the brains and bodies of people with mental illness since the 1940's. > We have a plethora of scientific research to support this. > https://twitter.com/ChrisPalmerMD/status/1675801721820332032 https://twitter.com/ChrisPalmerMD/status/1675801721820332032 I don't think the ketogenic diet is the best intervention, but it's a start. My friend figured out that she's a poor methylator who is harmed by the food fortification folic acid. Adding a methylated form of Vitamin B-9 to her routine flipped a switch for her, from "depressed" to "not-depressed", but the mental health professionals forced on her didn't care. Dr. Palmer tweeted about his professional colleagues hurting people like my friend with anti-psychotics. While tranquilizers make the patient's symptoms seem better, they also harm the patient's metabolism. Whoops. This submission about ultra-processed foods was on the front page earlier today: https://news.ycombinator.com/item?id=40486504 https://news.ycombinator.com/item?id=40486504

AtlasBarfed 2y ago

I get depression and activity/exercise aren't easy to marry, but exercise and getting fit seems like a much better thing to try before mdma or LSD burns. Exercise is supposedly superior to all pharma antidepressants. And in the vein of the metabolic stuff, exercise can change your gut bacteria and metabolism on a fundamental level that isn't as fringe, it's pretty well documented. But it takes like a month to get the train rolling, no pill popping. Exercise helps with sleep regulation. Exercise helps with pooping regularly. Exercise helps moderate appetite, excessive or inability to eat. A very underrated aspect is it increases your pain threshold. Depressives have tested as less pain tolerant and if the correlation is a factor, exercise helps. There's probably 20 other aspects.

lll-o-lll 2y ago
Seconding exercise is the single best and easiest way to help. Intense exercise, but can be short. Consult the GP before flogging yourself to avoid unexpected death.
krzat 2y ago
Exercise, therapy and some kindness/compassion mindfulness. Very powerful stuff.

eellpp 2y ago

Will read through this. But have a quick question: Would it not be reasonable to guess that people having mental issues will have metabolic issues developed as later side effects. The reason is that mental issues puts a person in confused/lost state along with all the anxiety/feelings that it induces. This will causes them to neglect taking care of their body needs. Then that should trigger metabolic changes.

bentt 2y ago

Yes. I scanned the OP link for any mention of nutrition, the gut or microbiome and there was nothing. Such a disappointing oversight for a supposed expert on depression.