As far as I can tell, there’s very little one can do for any extended time without creating epigenetic changes. Epigenetic changes are durable changes in gene e

As far as I can tell, there’s very little one can do for any extended time without creating epigenetic changes. Epigenetic changes are durable changes in gene expression within the cell - we already know that fasting or food deprivation create epigenetic changes, and the mechanism of cell differentiation generally (muscle vs liver cells, say) is epigenetic. I’m not going to defend long-term high-level cannabis usage - I’ve got eyes - but I’d suspect we’re going to find more things in the “causes epigenetic effects” bucket than not.