I used Gentoo for many many years, but at work where I didn't had powerful enough CPU I had to compromise and switched to Fedora, when you enable additional rep

I used Gentoo for many many years, but at work where I didn't had powerful enough CPU I had to compromise and switched to Fedora, when you enable additional repos (eg. rpmsphere) software availability is pretty good, there is also copr so you can use one of community maintained repos. They are not on the top with compiler optimizations (based on phoronix benchmarks) but are fairly close, probably because they tend to trade security for performance. If you want things to just work I recommend using one of deb or rpm distributions as you can count that those will have official packages for anything you might need