I'm not a biochemist, but that unreactive property likely contributes to persistence and bioaccumulation, and like with microplastics, silica, and asbestos, tri

I'm not a biochemist, but that unreactive property likely contributes to persistence and bioaccumulation, and like with microplastics, silica, and asbestos, trigger an immune response, cause release of inflammatory cytokines or fibrosis. PFAS can in fact bind to specific proteins in the blood, like albumin as well and other proteins in the liver and kidneys. PFAS molecules have structural similarities to natural hormones, particularly thyroid and allows it to bind to hormone receptors creating agonistic or antagonistic effects.