3 ms·

A replication study failed to confirm the result. DOI: 10.1001/archpedi.160.11.1121 DOI: 10.1016/s0093-3619(08)70425-8 DOI: 10.1016/s0084-3954(08)70300-2

• pessimizer 2y ago
  Relevant, but 3x as many children had the wart disappear entirely for duck tape as opposed to placebo, which was not significant due to the size of the sample and because total disappearance was rare overall (which are a result of choosing "complete resolution" in 6 weeks as a thing to pay attention to and the power of the study itself to find differences in such a rare outcome.) It also found 27% size reduction for duck tape vs. 9% for placebo, which was significant. > Complete resolution of the treated wart was seen in only a few children. The first resolution in both the duct tape and placebo groups was noted after 4 weeks. At the end of the study, after 6 weeks, the warts of 8 children (16%) in the duct tape group and the warts of 3 children (6%) in the placebo group had disappeared (Table 2), resulting in a number needed to treat of 10 (95% confidence interval, 5 to ⬁). This difference was not statistically significant. > In the duct tape group, there was a diameter reduction of 27% (from a mean of 4.6 mm to 3.4 mm) after 6 weeks. In the placebo group, this was 9% (from 4.4 mm to 4.0 mm). When adjusted for the baseline diameter, this resulted in a statistically significant difference in diameter reduction of 1.0 mm between the 2 groups (P=.008). https://doi.org/10.1001/archpedi.160.11.1121 https://doi.org/10.1001/archpedi.160.11.1121
• andrewla 2y ago
  I can't find the second two; the first one [1] is simply inconclusive; small sample sizes but no real effect. Crucially, this one compares duct tape to placebo (a corn pad, which seems to be a foam ring that surrounds but does not cover the wart). The original study is from 2002, the first study linked above is from 2006. [1] https://pubmed.ncbi.nlm.nih.gov/17088514/ https://pubmed.ncbi.nlm.nih.gov/17088514/