4 ms·

That link doesn't make a claim quite that strong. I also don't know anyone that has eaten it. Given that I know dozens of people who demonstrably lost their se

That link doesn't make a claim quite that strong. I also don't know anyone that has eaten it. Given that I know dozens of people who demonstrably lost their sensitivity to poison oak via the accidental chronic exposure regimen I outlined above, at the very least it should raise a scientific question. It would be easier to dismiss if it was an isolated case or two. No one exposes themselves like that intentionally.

echelon 2y ago
> lost their sensitivity to poison oak via the accidental chronic exposure regimen This is not how the immune system is known to work. Sensitivity does not downregulate. Increased exposure enhances detection and response. Recognition proliferates. Once you're allergic to something, it'll only worsen. You can become allergic to new things, but you won't lose allergies unless the recognizer population dies off entirely. And even if it did, you're likely close enough to training your immune system to this sensitivity again. (You've already done it at least once.) It's a failure mode of adaptive immunity.
- 01100011 2y ago
  I've lost allergies to chocolate and soy. If you can't lose allergies, why is exposure therapy a thing?
  - echelon 2y ago
    You're training a different kind of immune sensitivity. You're still inducing inflammation, and you're still allergic, you just see less IgE response.
  - paulgerhardt 2y ago
    Simply because you’re both right. One is correct in that repeated exposure to an allergen can upregulate IgE production, especially in cases of severe allergies like bee stings or peanuts. This is due to the immune system's sensitization process, where each exposure can lead to more intense reactions, driven by the Th2-mediated immune response that promotes IgE production and allergic inflammation. However, one is also correct that controlled exposure through allergen immunotherapy (SCIT or SLIT) can downregulate IgE and mitigate allergic responses. This therapy works by gradually introducing the allergen in controlled doses, which shifts the immune response from a Th2-dominated profile to a Th1-dominated or regulatory T cell (Treg) profile. This shift reduces IgE levels and increases the production of blocking antibodies like IgG4, leading to long-term desensitization and reduced allergic reactions. In particular environmental allergens (pollens, dust mites, animal dander, molds), insect venoms (bee, wasp) may respond well to immunotherapy but we’ve had poor success or disproportionate risk attempting to mitigate food allergens (peanuts, tree nuts, and shellfish), certain medications, and latex .
- armatav 2y ago
  How do allergy shots work?
- elevatedastalt 2y ago
  Looks like you are giving "Ackshually" technically correct points, when it's clear what others are trying to say. Please engage with what they are trying to convey instead of coming up with technical gotchas.
  - deleted 2y ago
    [deleted]
- cyberax 2y ago
  > You can become allergic to new things, but you won't lose allergies unless the recognizer population dies off entirely. That's not true. Desensitization therapy often works. The trick is to introduce the allergens into the bloodstream, bypassing the skin.
  - kelnos 2y ago
    I don't think that's necessary. I've been doing allergy immunotherapy for the past few years, and it's all subcutaneous. Definitely not into the bloodstream.
- kelnos 2y ago
  > Sensitivity does not downregulate. Increased exposure enhances detection and response. Recognition proliferates. Once you're allergic to something, it'll only worsen. I don't think that's correct. If it were, then allergy immunotherapy wouldn't work. Which... it does. Not perfectly, and not for everyone, but it does for many.

echelon 2y ago

> lost their sensitivity to poison oak via the accidental chronic exposure regimen This is not how the immune system is known to work. Sensitivity does not downregulate. Increased exposure enhances detection and response. Recognition proliferates. Once you're allergic to something, it'll only worsen. You can become allergic to new things, but you won't lose allergies unless the recognizer population dies off entirely. And even if it did, you're likely close enough to training your immune system to this sensitivity again. (You've already done it at least once.) It's a failure mode of adaptive immunity.

01100011 2y ago
I've lost allergies to chocolate and soy. If you can't lose allergies, why is exposure therapy a thing?
- echelon 2y ago
  You're training a different kind of immune sensitivity. You're still inducing inflammation, and you're still allergic, you just see less IgE response.
- paulgerhardt 2y ago
  Simply because you’re both right. One is correct in that repeated exposure to an allergen can upregulate IgE production, especially in cases of severe allergies like bee stings or peanuts. This is due to the immune system's sensitization process, where each exposure can lead to more intense reactions, driven by the Th2-mediated immune response that promotes IgE production and allergic inflammation. However, one is also correct that controlled exposure through allergen immunotherapy (SCIT or SLIT) can downregulate IgE and mitigate allergic responses. This therapy works by gradually introducing the allergen in controlled doses, which shifts the immune response from a Th2-dominated profile to a Th1-dominated or regulatory T cell (Treg) profile. This shift reduces IgE levels and increases the production of blocking antibodies like IgG4, leading to long-term desensitization and reduced allergic reactions. In particular environmental allergens (pollens, dust mites, animal dander, molds), insect venoms (bee, wasp) may respond well to immunotherapy but we’ve had poor success or disproportionate risk attempting to mitigate food allergens (peanuts, tree nuts, and shellfish), certain medications, and latex .
armatav 2y ago
How do allergy shots work?
elevatedastalt 2y ago
Looks like you are giving "Ackshually" technically correct points, when it's clear what others are trying to say. Please engage with what they are trying to convey instead of coming up with technical gotchas.
- deleted 2y ago
  [deleted]
cyberax 2y ago
> You can become allergic to new things, but you won't lose allergies unless the recognizer population dies off entirely. That's not true. Desensitization therapy often works. The trick is to introduce the allergens into the bloodstream, bypassing the skin.
- kelnos 2y ago
  I don't think that's necessary. I've been doing allergy immunotherapy for the past few years, and it's all subcutaneous. Definitely not into the bloodstream.
kelnos 2y ago
> Sensitivity does not downregulate. Increased exposure enhances detection and response. Recognition proliferates. Once you're allergic to something, it'll only worsen. I don't think that's correct. If it were, then allergy immunotherapy wouldn't work. Which... it does. Not perfectly, and not for everyone, but it does for many.