They don't really map well. The brain obviously operates on more continuous principles rather than binary states. The relationship between excitation/inhibition

They don't really map well. The brain obviously operates on more continuous principles rather than binary states. The relationship between excitation/inhibition and emergent effects may be more direct and graded in biological neural networks vs to the "active when low". Buuuutt stiilll, 5-HT2A receptor and its downstream effects on glutamate transmission play a central role in mediating the subjective effects of psychedelics. Very very many studies have consistently linked 5-HT2A activation to the perceptual, cognitive, and emotional characteristic of the psychedelic state. Disruption of the default mode network and other changes are somewhat important maybe, the 5-HT2A receptor appears to be the focus of action for producing these effects. The point being, neurochemical interactions at the molecular level are the most important aspects of the LSD interaction, so.., now sure how that works in the context of synthetic AI, I don't know much about ML/NN.