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My understanding is that GLP-1 affects appetite, and thus affects diet. And one of the reasons people quit GLP-1 long-term is because they miss eating and enjoy

My understanding is that GLP-1 affects appetite, and thus affects diet. And one of the reasons people quit GLP-1 long-term is because they miss eating and enjoying food.[1] > The drugs work by activating GLP-1 receptors in the body in a way that reduces appetite, alters gut function, and may impact addiction pathways.[2] However, adherence to the drugs long-term is a challenge, as many people stop taking them after some time. [1]: https://youtu.be/d3X3HPp44b8?t=951 https://youtu.be/d3X3HPp44b8?t=951 [2]: https://youtu.be/d3X3HPp44b8?t=239 https://youtu.be/d3X3HPp44b8?t=239

matthewdgreen 2y ago
Right. There is clearly a powerful system in the human brain and body that controls our appetite and weight set point. Medications that adjust that system seem to produce durable changes in appetite and obesity, while typical changes to diet and exercise see weight revert to the mean after a year or so. So the question is whether there are other substances in our diet that are also affecting this system. This isn’t crazy: various gut bacteria produce proteins that increase natural GLP-1 in the body. So any substance that disrupts these bacteria could easily have this sort of effect. https://www.nature.com/articles/s41564-021-00880-5 https://www.nature.com/articles/s41564-021-00880-5