My main, everyday use at the moment is I use it to run a Chinese dictionary software called Wenlin. Its THE Chinese dictionary software, for Desktop at least.

My main, everyday use at the moment is I use it to run a Chinese dictionary software called Wenlin. Its THE Chinese dictionary software, for Desktop at least. Interestingly, if you have access to the source, which takes some effort but is available after some paperwork, it has tools to compile specifically for greater Wine compatibility. Besides that, I run Excel 2003, because nothing else even comes close to the power of Excel+VBA. I also run some old multimedia educational software, as well as a multimedia Encyclopaedia Britannica. A really nice tool to work with timing transcripts to audio and then using them for shadowing/chorusing, called WorkAudioBook. Some old typing tutors for Chinese. Would LIKE to run Paint.NET like someone mentioned elsewhere. Winamp and foobar2000, two media players that are simply unbeaten by anything on Linux, and believe me I've tried everything. Although at the moment I'm committed to running mpd, so they're not getting as much use now. Also games obviously.