3 ms·

Equvalent to saying Alcohol is toxic amongst a sample of people that died due to drunk driving. It appears thar heat stroke caused the problems not "toxic MDMA

Equvalent to saying Alcohol is toxic amongst a sample of people that died due to drunk driving. It appears thar heat stroke caused the problems not "toxic MDMA concentrations". The LD50 of MDMA is estimated to be 180mg/kg - Were those ravers taking tens of capsules? I presume there are toxicology reports from the deaths that estimated the dosages. But alcohol is poisonous if you have too much - we don't usually call it "toxic". Weirdly they mention "a warm ambient environment" but what were the humidity levels? I presume there is good information on the underlying causes of death elsewhere? That summary is terribly uninformative. "mortality from classic heat stroke approaches 80% and, for exertional heatstroke, 33% in the absence of prompt treatment" : https://www.nejm.org/doi/full/10.1056/NEJMcp2210623 https://www.nejm.org/doi/full/10.1056/NEJMcp2210623 Disclaimer: personally I'm not a MDMA user. I'm a concerned citizen that thinks raves are generally healthier than bars. "sensible" MDMA usage anecdotally within those events seems safe to me (sample of thousands of people, zero deaths). Number of people I know dead from MDMA: zero. Number of people I personally know dead from alcohol: many (I am a middle aged guy so some were long term effects, one was in a house fire).

Retric 2y ago
MDMA is one of many drugs that interferes with temperature regulation. It’s a direct contributing factor and they wouldn’t have had severe medical issues without taking it. Drunk driving is a more indirect risk, but I am also including that as one of the risks of Alcohol consumption elsewhere in the thread. If you’re objecting to the name fine, but the risk still exists as MDMA consumption regularly kills people due to this and other risks. PS: Water toxicity is a similar situation. It’s not just the amount of water alone that’s a problem instead the amount they’ve been sweating is often a contributing factor. Oddly, they also mention MDMA as a risk: https://en.wikipedia.org/wiki/Water_intoxication https://en.wikipedia.org/wiki/Water_intoxication

Retric 2y ago

MDMA is one of many drugs that interferes with temperature regulation. It’s a direct contributing factor and they wouldn’t have had severe medical issues without taking it. Drunk driving is a more indirect risk, but I am also including that as one of the risks of Alcohol consumption elsewhere in the thread. If you’re objecting to the name fine, but the risk still exists as MDMA consumption regularly kills people due to this and other risks. PS: Water toxicity is a similar situation. It’s not just the amount of water alone that’s a problem instead the amount they’ve been sweating is often a contributing factor. Oddly, they also mention MDMA as a risk: https://en.wikipedia.org/wiki/Water_intoxication https://en.wikipedia.org/wiki/Water_intoxication