Sinclair is now using epigenetic regprogramming with OSK (developmental) genes to effectively regrow the severed optic nerve in primates and proceeding to human

Sinclair is now using epigenetic regprogramming with OSK (developmental) genes to effectively regrow the severed optic nerve in primates and proceeding to humans. Levin has mouse paws cut off in a similar way and regrows them in a wearable bioreactor with a mix of drugs, which include not only "electroceuticals" (ion channel modulators), but probably also some (growth) hormones or hormone precursors (as he mentioned in a podcast they may use some estrogen precursor). Yea, they regenerate ~70% of the whole paw with multiple tissues, but the end result seems the same if it would be obtained by OSK reprogramming. In a recent podcast #300 Attia was again mentioning the rather reliable benefits of caloric restriction. So thermodynamically it still seems ridiculous that by reducing the inflow of energy (at least the one of the most well-known type) the biological (and presumable computational) efficiency is increased at literally no cost.