4 ms·

"Large dose" doesn't mean the same thing as "overdose". For context, the LD50 for MDMA is 160 mg/kg for rats. MDMA screws up the body's ability to regulate tem

"Large dose" doesn't mean the same thing as "overdose". For context, the LD50 for MDMA is 160 mg/kg for rats. MDMA screws up the body's ability to regulate temperature. But without the warm environment and physical activity leading to hyperthermia, I can't imagine any of those people would have even needed medical attention. That said, personally I would never call MDMA "the poster child for safe illegal drugs". Just because it won't kill you, doesn't mean it is safe or risk-free.

Retric 2y ago
If you’re suffering significant medical issues from taking excessive amounts of a drug, that’s called an overdose. More broadly, I’m including traffic fatalities as a risk from alcohol and falls under LSD, so having deadly issues regulating body temperature definitely qualifies in an apples to apples comparison here.
- evanelias 2y ago
  > If you’re suffering significant medical issues from taking excessive amounts of a drug, that’s called an overdose. Again, no, that San Francisco situation is strictly not describing an overdose. From the comfort of your living room, you can consume a massively higher amount of MDMA than what was described in that paper, and won't suffer significant medical issues. > I’m including traffic fatalities as a risk from alcohol OK, but that doesn't mean a drunk-driving fatality is an overdose on alcohol.
  - Retric 2y ago
    What defines an overdose is the impact it has on your body not the specific quantity consumed. Thus you can OD on insulin even if the amount is needed at other times. If they had taken that much at home it may not have resulted in an overdose, but in this situation it did.
    - evanelias 2y ago
      Well, by that logic, if someone has a panic attack from consuming cannabis, you'd view them as "overdosing" on weed. I suppose you're free to say that, and everyone else is free to ignore this as ridiculous nonsense which is completely out-of-step with the widely-used definition of "overdose". You're completely ignoring the context of the event. Have you ever been to a rave? Some promoters are good and understand the importance of providing free/inexpensive water, proper ventilation, and security who are able to spot attendees requiring medical intervention. Other promoters are shady AF and do none of those things. In the latter case, if someone consumes MDMA and also dances for hours without hydration and the venue is way too hot / oversold, yes that person is at risk of hyperthermia. That can also happen even to sober people, I've literally seen it.
      - Retric 2y ago
        It’s a definition used by doctors not just me. Try asking your GP about what it an insulin OD entails and they will refer to the results not the specific dose. Though obviously there’s a dose large enough it’s never appropriate.
      - nicoburns 2y ago
        > Some promoters are good and understand the importance of providing free/inexpensive water And indeed some countries legally require it.

Retric 2y ago

If you’re suffering significant medical issues from taking excessive amounts of a drug, that’s called an overdose. More broadly, I’m including traffic fatalities as a risk from alcohol and falls under LSD, so having deadly issues regulating body temperature definitely qualifies in an apples to apples comparison here.

evanelias 2y ago
> If you’re suffering significant medical issues from taking excessive amounts of a drug, that’s called an overdose. Again, no, that San Francisco situation is strictly not describing an overdose. From the comfort of your living room, you can consume a massively higher amount of MDMA than what was described in that paper, and won't suffer significant medical issues. > I’m including traffic fatalities as a risk from alcohol OK, but that doesn't mean a drunk-driving fatality is an overdose on alcohol.
- Retric 2y ago
  What defines an overdose is the impact it has on your body not the specific quantity consumed. Thus you can OD on insulin even if the amount is needed at other times. If they had taken that much at home it may not have resulted in an overdose, but in this situation it did.
  - evanelias 2y ago
    Well, by that logic, if someone has a panic attack from consuming cannabis, you'd view them as "overdosing" on weed. I suppose you're free to say that, and everyone else is free to ignore this as ridiculous nonsense which is completely out-of-step with the widely-used definition of "overdose". You're completely ignoring the context of the event. Have you ever been to a rave? Some promoters are good and understand the importance of providing free/inexpensive water, proper ventilation, and security who are able to spot attendees requiring medical intervention. Other promoters are shady AF and do none of those things. In the latter case, if someone consumes MDMA and also dances for hours without hydration and the venue is way too hot / oversold, yes that person is at risk of hyperthermia. That can also happen even to sober people, I've literally seen it.
    - Retric 2y ago
      It’s a definition used by doctors not just me. Try asking your GP about what it an insulin OD entails and they will refer to the results not the specific dose. Though obviously there’s a dose large enough it’s never appropriate.
    - nicoburns 2y ago
      > Some promoters are good and understand the importance of providing free/inexpensive water And indeed some countries legally require it.