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Sleep does not help brain wash out toxins, study suggests
- olig15 2y agoObviously the article leave a lot of the science out, but this sounds like it’d be an easy thing to test for (which they’ve now done). Why wouldn’t this have been done years ago - I’m not trying g to say they should have done it earlier, as I genuinely don’t know. Is the tech to check this new? How much other science has been based off of this theory in the meantime?
- coldtea 2y agoDid they test it succesfully? Did they make some blunder? Did they misrepresented the importance of their results? Will it replicate? Does it apply to humans? I wouldn't be bothered with putting much faith on any of the papers coming out, unless I was a researcher in that space. The dust is far from settled.
- olig15 2y agoOh me neither, I’m less interested in the results and more that (to someone who has no idea behind the science - me), I’m surprised to hear it’s just now only being tested when I’ve heard this was the main theory of sleep for years.
- lambdaba 2y agoWhat about this? Sleep Drives Metabolite Clearance from the Adult Brain (2014) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880190/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880190/ > Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.
- keepamovin 2y agoExactly, the flushing effect. Which you can also feel when you do some forms of meditation :)
- jcutrell 2y agoI'm curious - do you have a physical sensation when this happens to you? Is there any evidence to support this claim? I ask because I often feel similar to brushing my teeth when I meditate, it's hard to explain though.
- lukan 2y agoI can relate, but I interpret it as mental cleaning. Letting go of garbage thoughts etc, not literal toxins through the blood, but I assume it also helps this process, by relieving of stress. A body under stress works intentionally different, than a relaxed body. (Stress means some kind of threat, not the time to do cleaning)
- keepamovin 2y agoHm, there's that, sure. But I get it physically tho, too. I actually feel this: the pumping. It's only a certain type of focus tho. You may not yet have attained it, or perhaps not everyone is physically capable. But I'm happy to try to teach you to do it: reach out to me heh :)
- keepamovin 2y agoBrushing your teeth? That's interesting heh! :) On that: a buzzing sensation in your teeth? Yeah, I can relate. I think it's down to increased sensitivity to the nerves in your teeth that you normally don't pay attention to, but can be apparent when modifying your attention as in meditation. It could be something else, tho! :) To your question on me: I feel this physically. This is not a 'claim', it's evidence: that I'm saying this to you.
- lm28469 2y agoYou have no physical sensors that would allow you to "feel" events up there.
- AndrewDucker 2y agoWhat about this, from a month ago: https://arstechnica.com/science/2024/04/sleeping-more-flushes-junk-out-of-the-brain/ https://arstechnica.com/science/2024/04/sleeping-more-flushe... Which seems to very clearly show that the brain flushes things out when we're asleep.
- freddie_mercury 2y agoIt doesn't show that. All your article says is that neuron trigger the gylmphatic system to create waves. It doesn't establish that the waves actually remove more waste product. It doesn't even actually establish that the waves cause more flow. They are simply a "plausible mechanism to explain the correlated flow".
- keepamovin 2y agoI have anecdotal evidence from a long term study (~40 years) that suggests otherwise hahaha! :) tho I know some amount of sleep can reduced naturally using certain forms of seated meditation.
- bionhoward 2y ago*toxicants
- neglesaks 2y agoAt this point most of my cerebrospinal fluid is replaced with coffee, so I don't know what my brain is supposed to clear out during sleep.
- BaculumMeumEst 2y agothanks for the reminder to start brewing cup no 3
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- OutOfHere 2y agoWhy then does one feel refreshed after a nap? I assert that dreams are a co-necessity for the effect. Sleep without sufficient dreams won't achieve it.
- iamthejuan 2y agoI wonder how sleeps affected our brain, and how there is a man who do not sleep for decades and does not lose energy.