4 ms·
Genuine question: how do we know that's not just a side effect instead of a driver?
by asdfman123 2y ago
Genuine question: how do we know that's not just a side effect instead of a driver?
- grumpy-de-sre 2y agoDr. Blakelys lab has produced knock-in mice with the rare SERT variants described, and they have exhibited the behavioral and biochemical markers of ASD. It's actually a very remarkable finding. They also saw a reduction in ASD symptoms by pharmaceutically blocking the offending inflammatory pathways. So I think at-least for the tiny fraction of ASD patients with these rare SERT variants there's actually a chance that they are a major driver of the disorder. Regardless it provides a tantalizing look at some of the upstream pathways that could be involved more generally. I think we're going to find the disorder is very heterogenous and there will be many different subtypes and pathways involved.