To be honest, apart from the containment systems you mentioned, much of biology basic research doesn't actually need that much sophisticated kit for basic cloni

To be honest, apart from the containment systems you mentioned, much of biology basic research doesn't actually need that much sophisticated kit for basic cloning and genetic manipulation. A lot of the key reagents can just be bought - and BTW it's why code like Screepy exist ( https://edinburgh-genome-foundry.github.io/ https://edinburgh-genome-foundry.github.io/ ),. I think the real thing that stops it - it not that you can't make stuff that kills people, but the problem of specificity - ie how do you stop it killing yourself.