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Is alphafold doing model generation or is it just reducing a massive state space? The current computational and systems biochemistry approaches struggle to mod
by signal_space 2y ago
Is alphafold doing model generation or is it just reducing a massive state space?
The current computational and systems biochemistry approaches struggle to model large biomolecules and their interactions due to the large degrees of freedom of the models.
I think it is reasonable to rely on statistical methods to lead researchers down paths that have a high likelihood of being correct versus brute forcing the chemical kinetics.
After all chemistry is inherently stochastic…