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Nicotine use without smoking raises heart rate, constricts blood vessels, raises blood pressure, and remodels the cardiovascular system and individual cells. Th

Nicotine use without smoking raises heart rate, constricts blood vessels, raises blood pressure, and remodels the cardiovascular system and individual cells. Those cardiovascular changes are associated with stroke and dementia. It stimulates the mesolimbic dopamine system which causes downregulation of dopamine receptors, addiction, and feeling less good when you aren't ingesting nicotine. Here is an overview: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026694/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026694/

dyauspitr 2y ago
There isn’t a single mention of dementia in that paper. The only mention of stroke is associated with cigarette smoking. It talks primarily about nicotine’s effect on the vascular system and the effects seem minimal, even in mice. Here’s a pretty comprehensive list of the benefits of nicotine and the lack of significant side effects. https://gwern.net/nicotine#benefits https://gwern.net/nicotine#benefits Here’s the conclusion he came up with after significant perusal of the research “Nicotine is pretty much harmless, the studies are clear, the relevant areas & studies comprehensible with not too much work, and I feel I can discuss it with a clean conscience. Really, about the worst you can say about pure nicotine use is that it might be a gateway to tobacco or that one’s blood pressure might increase, which are issues that can be easily addressed empirically via additional studies/surveys or by eg. measuring one’s own blood pressure after taking nicotine, respectively.”
fermisea 2y ago
Linking nicotine to dementia, which study? For all the other things, the same can be said about coffee. Are we banning coffee?
- mtlguitarist 2y ago
  Except coffee is associated with lower all cause mortality (likely due to the amount of fiber extracted in coffee drinks) [0]. Do you have any evidence of decreased all cause mortality associated with any nicotine product? https://youtu.be/IBB_8vR7wpU?si=0Cmq26oBQ-9dwUNN https://youtu.be/IBB_8vR7wpU?si=0Cmq26oBQ-9dwUNN

dyauspitr 2y ago

There isn’t a single mention of dementia in that paper. The only mention of stroke is associated with cigarette smoking. It talks primarily about nicotine’s effect on the vascular system and the effects seem minimal, even in mice. Here’s a pretty comprehensive list of the benefits of nicotine and the lack of significant side effects. https://gwern.net/nicotine#benefits https://gwern.net/nicotine#benefits Here’s the conclusion he came up with after significant perusal of the research “Nicotine is pretty much harmless, the studies are clear, the relevant areas & studies comprehensible with not too much work, and I feel I can discuss it with a clean conscience. Really, about the worst you can say about pure nicotine use is that it might be a gateway to tobacco or that one’s blood pressure might increase, which are issues that can be easily addressed empirically via additional studies/surveys or by eg. measuring one’s own blood pressure after taking nicotine, respectively.”

fermisea 2y ago

Linking nicotine to dementia, which study? For all the other things, the same can be said about coffee. Are we banning coffee?

mtlguitarist 2y ago
Except coffee is associated with lower all cause mortality (likely due to the amount of fiber extracted in coffee drinks) [0]. Do you have any evidence of decreased all cause mortality associated with any nicotine product? https://youtu.be/IBB_8vR7wpU?si=0Cmq26oBQ-9dwUNN https://youtu.be/IBB_8vR7wpU?si=0Cmq26oBQ-9dwUNN