The ergonomics of a full-size keyboard are atrocious, because they weren't designed with mice in mind. You've got a relatively unimportant set of keys occupying

The ergonomics of a full-size keyboard are atrocious, because they weren't designed with mice in mind. You've got a relatively unimportant set of keys occupying the exact piece of desk space that a mouse should be. Unless your shoulders are three feet wide, you'll either end up with your QWERTY keys too far to the left, your mouse too far to the right, or some awkward compromise. If you really need a num pad - most people don't - then you can get a separate one and position it to the left of your keyboard.