Relative to the amount of money and research that has gone into antidepressants over the last four decades, they have performed very very poorly with respect to

Relative to the amount of money and research that has gone into antidepressants over the last four decades, they have performed very very poorly with respect to their intended goal. They are not highly effective for most people, and even when they do help people, there are a large number of unpleasant side effects, including sexual problems, weight gain, and fatigue, just to name a few (also, feeling fat, tired, and impotent is a great way to continue being depressed). Many commonly-used antidepressants also cause mild to severe withdrawal systems when people go to stop or change medications. So the reason we have people exploring psychedelics is not wishful thinking, but a reflection of the fact that we don't have effective treatments for depression that help most people, which most doctors will freely admit off the record.