If the immune system actually works properly, no, not really a huge concern. Leukocytes and macrophages fully consume foreign matter, enclosing it in a phagosom

If the immune system actually works properly, no, not really a huge concern. Leukocytes and macrophages fully consume foreign matter, enclosing it in a phagosome. This then merges with a lysosome, where the matter is broken down into harmless components, although some stays on the surface of the cell to activate other immune cells against that particular brand of gunk.