If you do go down this rabbit hole, you probably want to optimize hand alternation. That is, it is not enough to keep the high value letters home row, you prob

If you do go down this rabbit hole, you probably want to optimize hand alternation. That is, it is not enough to keep the high value letters home row, you probably want to split them between hands, while keeping them home row. Similarly, the slowest combinations of characters will be the ones that force a finger to go from top to bottom row. On qwerty, as an example, 'cemetery' would be pretty bad for the opening two letters.