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Say what you want but pharmaceuticals are perhaps the only hope America has against the obesity epidemic.

by djsudysgcc 2y ago

toomuchtodo 2y ago
Or GLP-1 pathway targeted gene therapy.
- djsudysgcc 2y ago
  Interesting is anyone doing it?
  - toomuchtodo 2y ago
    Fractyl Health. https://www.fractyl.com/fractyl-health-demonstrates-significant-improvement-in-glucose-control-and-obesity-inpreclinical-studies-of-its-rejuva-glp-1-based-pancreatic-gene-therapy-glp1-pgtxcompared-to-chronic-semaglutide-at/ https://www.fractyl.com/fractyl-health-demonstrates-signific... (no affiliation, just very interested in a permanent fix that scales vs chronic mgmt with a pharma product)
    - djsudysgcc 2y ago
      Trial starting this year and listed on a stock exchange meaning there should be lots of good info disclosed ! Cool thank you
jpk 2y ago
That's certainly a take, but without reasoning or evidence, this isn't a very interesting comment.
- ceejayoz 2y ago
  The epidemic itself is pretty strong evidence. Gastric bypass and these new drugs are basically the only proven effective ways of reliably helping people lose.
  - InsaneOstrich 2y ago
    I mean, most of those people could just exercise or change their diets instead of relying on expensive drugs with unknown long term side effects
    - ceejayoz 2y ago
      Except they can’t. We know this. Telling obese people “just change your diet and exercise” has roughly the success rate as hiring a witch to cast a spell.
  - jpk 2y ago
    There are cultures in which obesity is rare and yet they achieve it without drugs and surgery. That itself is pretty strong evidence that the claim that they're the only things that could possibly help is wrong. I'm glad those are options, because they certainly do help people, but if you take that and run with "welp, more pharma is the only way!" then you're not thinking very hard.
    - ceejayoz 2y ago
      Well gee, if all we have to do is change our entire culture, that sounds easy!
      - jpk 2y ago
        I mean, I didn't say it was. Most things worth doing aren't easy. Listen, all I'm saying is we should strive for something better than to be content with producing lots of obese people and then "fix" them with drugs. Pharma would love that, I'm sure, but it's a tactical fix that needs a strategic solution.
Osmium 2y ago
Or better regulation. Treating refined sugar as the addictive substance it is, and keeping those products in a separate part of the store rather than at the checkout line. Removing subsidies for unhealthy ingredients, subsidising healthier ones. More education in schools. Better funding and requiring school districts to meet certain quality standards for the food they provide to children. Ensuring all children have the right to a healthy meal. Where previous initiatives have fallen short, critically evaluate why and make them better. Thinking about social psychological factors for our collective mental health and thinking about how this influences our dietary and exercise choices. There are lots of actions that could be taken that are not just pharmaceutical.
- WWLink 2y ago
  lol regulate it like cigarettes. 18+ to buy it, hidden behind the counter on that shelf that only shows the name part of the label. "Hi, can I get a ... snickers please?" "Ye but i'll have to see some ID first!"
- redserk 2y ago
  This is more than just children, the food environment adults are subject to encourages unhealthy habits too. Locking kitkats up won't change a thing. Just look at American portion sizes at any restaurant -- they're huge! The common mantra is that we want to ensure we get our money's worth. I was astounded on my trips to France. The dinners were still filling, but were much smaller than most American restaurants I've dealt with on the East Coast, Southeast, and Midwest. Plus we put sugar/HFCS in literally everything. If you wanted to save a few calories and eat a ham sandwich at home, the basic loaf of white bread you're yanking off the shelf has HFCS, and for what? This isn't even getting to the usual punching bag of fast food/fast casual, where you're easily set back 1000-1500kcals on the default menu selection.
downrightmike 2y ago
Sugars make people happy, fat and happy people don't revolt
- xenospn 2y ago
  Jan 6 mob had a lot of fatties. Just saying.

Say what you want but pharmaceuticals are perhaps the only hope America has against the obesity epidemic.

toomuchtodo 2y ago

Or GLP-1 pathway targeted gene therapy.

djsudysgcc 2y ago
Interesting is anyone doing it?
- toomuchtodo 2y ago
  Fractyl Health. https://www.fractyl.com/fractyl-health-demonstrates-significant-improvement-in-glucose-control-and-obesity-inpreclinical-studies-of-its-rejuva-glp-1-based-pancreatic-gene-therapy-glp1-pgtxcompared-to-chronic-semaglutide-at/ https://www.fractyl.com/fractyl-health-demonstrates-signific... (no affiliation, just very interested in a permanent fix that scales vs chronic mgmt with a pharma product)
  - djsudysgcc 2y ago
    Trial starting this year and listed on a stock exchange meaning there should be lots of good info disclosed ! Cool thank you

jpk 2y ago

That's certainly a take, but without reasoning or evidence, this isn't a very interesting comment.

ceejayoz 2y ago
The epidemic itself is pretty strong evidence. Gastric bypass and these new drugs are basically the only proven effective ways of reliably helping people lose.
- InsaneOstrich 2y ago
  I mean, most of those people could just exercise or change their diets instead of relying on expensive drugs with unknown long term side effects
  - ceejayoz 2y ago
    Except they can’t. We know this. Telling obese people “just change your diet and exercise” has roughly the success rate as hiring a witch to cast a spell.
- jpk 2y ago
  There are cultures in which obesity is rare and yet they achieve it without drugs and surgery. That itself is pretty strong evidence that the claim that they're the only things that could possibly help is wrong. I'm glad those are options, because they certainly do help people, but if you take that and run with "welp, more pharma is the only way!" then you're not thinking very hard.
  - ceejayoz 2y ago
    Well gee, if all we have to do is change our entire culture, that sounds easy!
    - jpk 2y ago
      I mean, I didn't say it was. Most things worth doing aren't easy. Listen, all I'm saying is we should strive for something better than to be content with producing lots of obese people and then "fix" them with drugs. Pharma would love that, I'm sure, but it's a tactical fix that needs a strategic solution.

Osmium 2y ago

Or better regulation. Treating refined sugar as the addictive substance it is, and keeping those products in a separate part of the store rather than at the checkout line. Removing subsidies for unhealthy ingredients, subsidising healthier ones. More education in schools. Better funding and requiring school districts to meet certain quality standards for the food they provide to children. Ensuring all children have the right to a healthy meal. Where previous initiatives have fallen short, critically evaluate why and make them better. Thinking about social psychological factors for our collective mental health and thinking about how this influences our dietary and exercise choices. There are lots of actions that could be taken that are not just pharmaceutical.

WWLink 2y ago
lol regulate it like cigarettes. 18+ to buy it, hidden behind the counter on that shelf that only shows the name part of the label. "Hi, can I get a ... snickers please?" "Ye but i'll have to see some ID first!"
redserk 2y ago
This is more than just children, the food environment adults are subject to encourages unhealthy habits too. Locking kitkats up won't change a thing. Just look at American portion sizes at any restaurant -- they're huge! The common mantra is that we want to ensure we get our money's worth. I was astounded on my trips to France. The dinners were still filling, but were much smaller than most American restaurants I've dealt with on the East Coast, Southeast, and Midwest. Plus we put sugar/HFCS in literally everything. If you wanted to save a few calories and eat a ham sandwich at home, the basic loaf of white bread you're yanking off the shelf has HFCS, and for what? This isn't even getting to the usual punching bag of fast food/fast casual, where you're easily set back 1000-1500kcals on the default menu selection.

downrightmike 2y ago

Sugars make people happy, fat and happy people don't revolt

xenospn 2y ago
Jan 6 mob had a lot of fatties. Just saying.