A very large percent, surely. It's why barbiturates or benzodiazepines or opioids have very rarely been used for strong sedation outside of a hospital setting

A very large percent, surely. It's why barbiturates or benzodiazepines or opioids have very rarely been used for strong sedation outside of a hospital setting. One person's sedating dose is another person's lethal overdose, with even slight mixing with alcohol or prescription antianxiety medications or painkillers. It is true ketamine doesn't affect breathing as badly as those drugs, and has fewer interactions, and is sometimes used in medical emergencies for sedation when the airway is a concern. That seems to have been what gave people the idea it could be used in paramedic settings, but less is not the same as no risk.